Pantnagar Journal of Research

Abstract

In the past few decades there have been indiscriminate uses of antibiotics due to which there have been increased antibiotic resistance in bacteria. Due to the constant use of conventional antibiotics, they have become ineffective against the superbugs. This has become a global emerging problem and several labs are working to adapt novel strategies to combat these superbugs. One of the promising candidates is gene silencing which involves binding of antisense oligonucleotides (ASOs) with the corresponding antibiotic resistant gene sequence inside bacterial cell. In this review, the gene silencing and carrier molecules involved in the process have been discussed in detail.