Pantnagar Journal of Research

Abstract

The acute toxic effects of profenofos were studied at a single dose of maximum tolerated dose (90 mg/kg bw) at 1 h 40 min (peak effect), 24 h and 14 days post-treatment in three treatment groups along with their respective control groups. There was no significant change in body weight and relative body weight gain in 1 h 40 min, 24 h and 14 days post-treatment groups as compared to control groups. A significant increase in relative organ weight of liver and right testis in 14 days posttreatment group was observed as compared to control group. Significant increase in relative organ weights of left testis and right epididymis was observed in 1 h 40 min post-treatment group as compared to control group. Histopathological lesions were observed in liver, kidney, brain and testes, suggesting its acute toxicity to these organs. No histopathological lesions were observed in bone marrow during acute toxicity study.